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Science Nation: Breakthrough in Early Cancer Detection

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      (Describer) Streams of light collide to create a globe filled with water. Title: Science Nation. A woman reports on television in front of a graphic saying “Barnstable This Morning”.

      [explosion]

      In order to vote in the November 8th election--

      (male narrator) For TV correspondent Melissa Chartrand, what started as some abdominal pain led to hysterectomy three years ago. They performed the hysterectomy, but when I woke up, they said, "You have ovarian cancer." I was in total shock.

      (narrator) Shock that was followed by grueling chemotherapy. With few early symptoms, ovarian cancer can be hard to detect. Early detection is absolutely not only key but probably the only way to win the war against cancer.

      (narrator) With support from the National Science Foundation, biomedical engineer Vadim Backman is shedding light on how to make early cancer detection cheaper, more accurate, and less invasive.

      (Backman) We're developing new optics technologies to learn about tissue structure and composition, and we're applying these technologies for early cancer screening.

      (narrator) They use a new type of microscopy, part of a field called "biophotonics." Backman's team demonstrates the process using cheek cells harvested with a brush.

      (Describer) They're wiped onto a slide.

      They then shine light on the harvested cells. Photons bounce off structures within them at different angles, depending on whether they are healthy or not. The process is highly sensitive and able to detect very subtle abnormalities, which could indicate problems elsewhere in the body.

      (Describer) Colors in the new images show greater differences inside a pre-cancerous cell than do black-and-white conventional images.

      (Backman) We see alterations in cells that are indicative of "pre-pre-cancer." If you looked at the cells in the microscope, you would not tell a difference.

      (narrator) Dr. Hemant Roy demonstrates this probe, currently in clinical trials, that uses biophotonics to analyze tissue inside the mouth for early lung cancer screening.

      (Describer) A probe is placed on the inside of a woman's cheek.

      With this probe, we've done probably a couple of hundred patients, and we're about 90% accurate.

      (narrator) Backman will soon lead a new clinical trial to screen cervical cells for signs of ovarian cancer, something Melissa Chartrand can appreciate.

      (Chartrand) If there had been a pre-screening tool or early detection, I might not have had to go through what I went through.

      (narrator) Using light to one day save lives.

      (Describer) A globe turns.

      For Science Nation, I'm Miles O'Brien.

      Transcript Options


      Now Playing As: English with English captions (change)

      There are only a few procedures that can detect very early signs of cancer. Those that do are often invasive, expensive, and uncomfortable. With support from the National Science Foundation, Vadim Backman of Northwestern University is developing technology that makes detecting cancer earlier. He’s doing it by shedding light on cancer cell development at the nanoscale level.

      Media Details

      Runtime: 2 minutes 33 seconds

      Computer screens with color-shaded images of a spiral shaped storm. Caption: study hurricanes, tornadoes, and blizzards from the inside.
      Science Nation
      Episode 1
      3 minutes 14 seconds
      Grade Level: 7 - 12
      Person filling a glass from a faucet. Caption: our risk of contracting some form of cancer would go up.
      Science Nation
      Episode 2
      3 minutes 9 seconds
      Grade Level: 7 - 12
      Green landscape with a hillside in the background. A small industrial installation is present. Caption: They don't know where to get information they can trust.
      Science Nation
      Episode 3
      3 minutes 7 seconds
      Grade Level: 7 - 12
      Robotic arms manipulating a small ball. Caption: is pushing the world of robotics and prosthetics
      Science Nation
      Episode 4
      3 minutes 47 seconds
      Grade Level: 7 - 12
      Bolt of lightning arcing from cloud to ground. Caption: we all want up-to-the-minute information.
      Science Nation
      Episode 5
      3 minutes 9 seconds
      Grade Level: 7 - 12
      Cluster of nerve fibers. Caption: that can image deep into biological tissue,
      Science Nation
      Episode 6
      3 minutes 6 seconds
      Grade Level: 9 - 12
      Dirty water with bubbles and PVC pipes. Caption: and reused again and again in a sustainable loop.
      Science Nation
      Episode 7
      3 minutes 4 seconds
      Grade Level: 9 - 12
      Person with a fabric cap strapped to their head. The cap has metal rivets and wires attached. Captions: (female) it feels maybe like a mild itchy or tingling sensation.
      Science Nation
      Episode 8
      3 minutes 3 seconds
      Grade Level: 9 - 12
      Microscopic image showing web-like structures and C shaped tubular organisms. Caption: (narrator) The soil itself is home to a vast number of tiny microbes,
      Science Nation
      Episode 9
      3 minutes 35 seconds
      Grade Level: 7 - 12
      White glowing orb against a black grid. Caption: Weakly Interacting Massive Particle
      Science Nation
      Episode 10
      3 minutes 19 seconds
      Grade Level: 10 - 12