The video "Origin of Everything: Why Are Prescription Drugs So Expensive?" explores the high cost of prescription medications in the United States. A part of the "Origin of Everything" series, the video delves into the history of drug regulation and the current pharmaceutical pricing landscape, emphasizing the difference compared to nations like Canada and Australia. Key concepts include the Drug Price Competition and Patent Term Restoration Act (Hatch-Waxman Act), and the role of pharmacy benefit managers (PBMs) in drug pricing. The video highlights how less stringent government policies and complex drug pricing negotiations contribute to the high costs, impacting uninsured individuals. It offers potential solutions such as increased price transparency and adopting a single-purchaser system, underscoring the necessity of understanding economic factors driving drug costs, which is crucial for informed decision-making and policy changes.